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Discover 8 Types of Adaptive Designs in Clinical Trials

Diane Potvin

Diane Potvin

Senior Statistical Advisor

Adaptive design is paving the way for more efficient and flexible studies. We are thrilled to present 8 types of adaptive designs that are shaping this transformation.

  • Group sequential
    Allows for one of more pre-planned interim analyses and incorporates predetermined criteria for adaptations.
  • Adaptation to the sample size
    Allows pre-planned adjustments to the sample size based on results from interim analyses.
  • Adaptation to the patient population
    Allows for adjustments to the patient population based on results from interim analyses. For instance, following results from interim analyses, enrolment could be restricted to a specific subpopulation.
  • Adaptations to treatment arm selection
    Allows for pre-planned modifications of treatment arms based on results from interim analyses (adding or terminating arms).
  • Seamless phase 2/3
    Design that integrates both Phase 2 and Phase 3 components within the same trial. The transition from Phase 2 and Phase 3 is conducted without interruption.
  • Adaptations to patient allocation
    Allows for adjustments to allocation of subjects to treatment group based on accumulating data during the trial.
  • Adaptation to endpoint selection
    Allows for adjustments to the selection of the primary endpoint based on results from interim analyses.
  • Adaptation to multiple design features
    Combines several adaptive designs.

Click here to download the PDF version.

For a comprehensive understanding, we recommend reading the full article available:  Potvin D, D’Angelo P, Bennett S, Jankicevic J, Bissonnette R. Adaptive designs in dermatology clinical trials: Current status and future perspectives. J Eur Acad Dermatol Venereol. 2024 Apr 15. doi: 10.1111/jdv.20030. Epub ahead of print. PMID: 38619384.

 

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Is Now

We are excited to announce that Innovaderm is rebranding our CRO division as Indero (in-dAIR-oh). This rebranding reflects our ongoing commitment to innovation and our expansion into the field of rheumatology, a therapeutic area closely linked to dermatology. As a dual-focus CRO specializing in both dermatology and rheumatology, this strategic decision marks a significant milestone for our organization, and we are eager to embark on this new chapter with our valued partners and clients. Additionally, our Clinical Research Unit (CRU) will keep the name Innovaderm and will continue to conduct dermatology studies.

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Our long-standing relationships with key opinion leaders and highly performing sites result in optimized start-up processes that deliver strong results in the least amount of time. As part of our site evaluation, our team utilizes past performance metrics, recruitment projections based on the competitive landscape, and detailed feasibility surveys to determine a site’s capabilities and interest in a study.

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We orchestrate all study activities and deliverables, including the site selection process, budget and contract negotiations, patient engagement, and recruitment enrollment projections, all while respecting your study timelines.

PROJECT MANAGEMENT

We orchestrate all study activities and deliverables, including the site selection process, budget and contract negotiations, patient engagement, and recruitment enrollment projections, all while respecting your study timelines.