Biometrics Archives

Episode 3: Edith Siméon—Estimands Unveiled

Episode Notes [email protected]: Use this email to let us know what you want to hear about. Estimands Unveiled Our expert today, with over two decades of industry experience, will guide us through the significance of estimands in the planification of clinical trials. We will be focusing on three key aspects: Purposes and requirements Cross-functional responsibility […]

Estimands in Clinical Trials

Table of contents Understanding Estimands Application of Estimands in Different Phases of Clinical Research Specifying Estimands for Secondary and Exploratory Endpoints Shared Cross-Functional Duties—Should estimand be only defined by biostatisticians? Benefits of Preliminary Conversation on Estimands Main Impacts of Statistical Analysis In essence, estimands are not a novel concept to clinical trials. The facets they […]

8 Advantages of Adaptive Design in Clinical Trials

Explore our latest infographic to get a comprehensive overview of the advantages of adaptive design. Patient Focus Limiting patient exposure to drugs or doses that are not sufficiently effective. Trial Efficiency Allowing trial completion with fewer patients, enriching the trial population in a subgroup of patients for whom the medication is effective. Early Termination Stopping […]

The Potential of Adaptive Design in Clinical Trials

Did you know? Adaptive design offers numerous benefits that streamline the drug-development process and bring life-changing medications to patients more rapidly. Adaptive Study Design Help With: Reducing the costs of drug development Contributing to reducing the length of the trial Reducing the time to bring a drug to the market Allowing patients to access to […]

Essential Requirements for Adaptive Designs in Clinical Trials

Adaptive design in clinical trials is a dynamic and innovative approach, but it requires certain key elements to ensure its successful implementation. Efficiency and Integrity The purpose of an adaptive trial design is to increase efficiency without compromising the integrity and validity of the results. For this to be accomplished, extensive and adequately maintained clinical […]

Discover 8 Types of Adaptive Designs in Clinical Trials

Adaptive design is paving the way for more efficient and flexible studies. We are thrilled to present 8 types of adaptive designs that are shaping this transformation. Group sequential Allows for one of more pre-planned interim analyses and incorporates predetermined criteria for adaptations. Adaptation to the sample size Allows pre-planned adjustments to the sample size […]